Description
Overview
IGF-1 LR3 (Long R3 Insulin-Like Growth Factor-1) is a research-grade synthetic analog of human IGF-1 with two key modifications: a substitution of Arg for Glu at position 3 and an additional 13-amino acid N-terminal extension. These modifications significantly reduce binding to IGF-binding proteins (IGFBPs), resulting in a substantially longer functional half-life compared to native IGF-1. This makes IGF-1 LR3 an essential research tool for studying growth factor signaling with enhanced bioavailability in experimental models.
Published Research
IGF-1 LR3 has been utilized in numerous research applications, including:
- Cell proliferation and differentiation assays across multiple tissue types
- IGF-1 receptor activation kinetics and MAPK/PI3K/Akt signaling cascades
- Myogenic satellite cell activation and skeletal muscle biology research
- IGFBP-independent signaling and receptor-level activity studies
- Stem cell culture maintenance and expansion protocols
- Comparative potency studies against native IGF-1 in cell culture systems
Specifications
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Molecular Weight: 9111 g/mol
- Solubility: Soluble in sterile water or 10mM HCl
- Storage: Store at -20°C for long-term stability. Reconstituted solutions should be used within 30 days when stored at 2–8°C
- CAS Number: 946870-92-4
Handling
This product is intended for laboratory research only. Reconstitute carefully with sterile water or dilute acid. Do not vortex — gently swirl to dissolve. Use aseptic technique during preparation. Refer to published literature for appropriate research concentrations.
For research and laboratory use only. Not for human consumption. Sold exclusively to qualified researchers and licensed institutions.
