Description
Overview
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a research-grade synthetic peptide originally identified as a mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome’s 12S rRNA gene. This 16-amino acid peptide has generated significant research interest as it represents a novel class of mitochondrial signaling molecules that can influence nuclear gene expression — a process known as retrograde signaling. MOTS-c is a valuable tool for studying the emerging field of mitochondrial-nuclear crosstalk.
Published Research
MOTS-c is a rapidly growing area of scientific investigation, with published research examining:
- AMPK activation and cellular energy sensing mechanisms
- Folate-methionine cycle regulation and one-carbon metabolism
- Glucose uptake and insulin sensitivity in skeletal muscle cell models
- Mitochondrial-nuclear communication (retrograde signaling) pathways
- Exercise-mimetic properties and metabolic adaptation in animal models
- Age-related decline in endogenous MOTS-c levels and aging biology
- Inflammatory cytokine modulation and immune cell metabolism
Specifications
- Purity: ≥99% (HPLC verified)
- Form: Lyophilized powder
- Molecular Weight: 2174.62 g/mol
- Sequence: MRWQEMGYIFYPRKLR
- Solubility: Soluble in bacteriostatic water or sterile water
- Storage: Store at -20°C for long-term stability. Reconstituted solutions should be refrigerated at 2–8°C
- CAS Number: 1627580-64-6
Handling
This product is intended for laboratory research only. Reconstitute with bacteriostatic water for research applications. Use aseptic technique during preparation. Refer to published literature for appropriate research concentrations.
For research and laboratory use only. Not for human consumption. Sold exclusively to qualified researchers and licensed institutions.
